[포스터] 만성 C형간염 환자에서 DAA 항바이러스제 치료 전후 효과와 임상수치 변화: 후향적 임상연구
2020년 추계학술대회 초록
- Mi Seon Parko,a,b, Young-Mo Yango,c, Ki Hyun Parkb, Hyo Cho Ahna, Ju Sin Kima and Eun Joo Choib, #
Department of Pharmacy, Jeonbuk National University Hospital, Jeonju, Koreaa
Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju, Koreab
Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Koreac
- Hepatitis C virus, Direct acting antivirals, Sustained virological response (SVR)
Direct-acting antivirals (DAAs) are recommended for the treatment of chronic hepatitis C virus in Korea. However, there are insufficient clinical studies on the efficacy and changes in clinical values before and after treatment for HCV infection in korean real-world setting. The aims of this study were to investigate the efficacy and changes in clinical values of direct-acting antiviral treatment in Korean patients infected with chronic hepatitis C virus genotype 1b or 2.
This was a retrospective study conducted with patient data obtained between August 2015 and August 2019 at Jeonbuk National University Hospital. The efficacy was evaluated through sustained virological response 12 weeks post-treatment (SVR12) via intention-to-treat (ITT) and modified intention-to-treat (mITT) analyses. The change in laboratory data was compared before and at the end of the treatment.
Of the 270 patients, SVR12 was achieved in 78.9% in ITT analysis, but 98.2% in mITT analysis. Of the 21.1% of all patients who did not achieve SVR12, majority of treatment failures were non-virologic failures (19.7%). After the DAA treatments, the mean levels of Hgb, alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase were significantly decreased. Meanwhile, the mean levels of platelets, international normalized ratio (INR), total bilirubin, albumin, and total cholesterol were significantly increased.
The DAA-based treatment has shown high efficacy in real-world setting. Non-virological factors, such as premature DAA discontinuation due to adverse events or a loss to follow-up, were the major causes for preventing achievement of SVR12. Acknowledgments This work was supported by the National Research Founda¬tion of Korea grant funded by the Korea government (NRF-2016R1C1B1015938).
- P-02. 박미선(전북대학교병원)-수정2.pdf