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[논문] 폐경기 여성에서 칼슘 제품간의 생체이용률 비교
Comparison of Calcium Bioavailibility of Four Commercial Calcium Supplements in Postmenopausal Women
Date

2002년 Vol.19 No.04

Authors
배성미, 양성희, 최선, 한옥연, 권혁상*, 윤건호*
가톨릭대학교 강남성모병원 약제과, 내과*
S.M.Bae, S.H.Yang, S.Choi, O.Y.Han, H.S.Kwon*, K.H.Yoon*
Department of Pharmacy, Department of Internal Medicine*,
Kangnam St. Mary's Hospital, Catholic University
#505 Banpo-dong, Seocho-gu, Seoul, Korea
Keyword
calcium, bioavailability, AUC, postmenopausal
Abstract
Despite the potential utility of calcium supplements in menopausal women, there are few data concerning the absorbability of different calcium salts. This four phase cross over study was conducted to compare pharmacokinetic indices of calcium absorption after a single oral administration(600mg as an elemental calcium). We selected calcium lactate and calcium gluconate, calcium carbonate, ergocalciferol complement(A), calcium carbonate and cholecalciferol complement(B) as calcium salts and vitamin D complexes, and calcium carbonate(C), calcium citrate(D) as mono calcium salts. In 8 healthy postmenopausal women aged 45-61(mean:54.9 years), venous blood samples were obtained for the measurement of serum calcium concentration before and at 1, 3, 5 hours after an oral ingestion of calcium. Compare the serum calcium concentration(mg/dl) after 1, 3, 5 hours after preload, at 3 hours A(0.613±0.557) and C(0.5±0.472) showed higher than D(-0.113±0.398), and at 5 hours A(0.650±0.607) and B(0.588±0.146) were higher than D(-0.075±0.296) (p<0.05). Among the four supplements only A(2.17±1.99) had greater change in area under the curve (ΔAUC1∼5hr, mg·hr/dl) of serum calcium from preload over 5 hours than D(-0.25±1.27)(p=0.012). We compared ΔAUC1∼5hr of C with D, and C with B, and A with B. Only C(1.57±1.42) had higher ΔAUC1∼5hr than D(-0.25±1.27, p=0.018). Comparing bioavailability of four commercial calcium supplements by ΔAUC1∼5hr calcium citrate(D) had relatively lower bioavailability and we couldn't convince that vitamin D complexes had higher bioavailability than mono calcium salts. Considering the similarity in bioavailability of each calcium supplements, it is favorable to select calcium supplements according to the patient compliance, simplicity of taking the medicine or medical cost.
Full-Text
2002-04-09.pdf