[논문] 골수이식시 Cyclosporine과 같은 경로로 투여되는 약물의 상호적합성에 관한 연구
The Compatibility of Cyclosporine with Commonly Used IV Drugs in BMT Unit During Y-site Delivery
2001년 Vol.18 No.01
- 정경주, 최승기*
포천중문의과대학교 분당차병원 약제부, 약리학 교실*
- Compatibility, Cyclosporine, BMT unit, Y-site delivery
The purpose of this study is to evaluate the physicochemical compatibility of cyclosporine with 20 selected drugs in BMT unit during simulated Y-site injection by visual inspection and turbidimetry. The results meeting the criteria for physical compatibility, admixtures were tested for concentrations of cyclosporine. Test solution of cyclosporine (1mg/ml) combined in a 1:1 ratio with secondary drugs in triplicate. Visual examinations were performed in fluorescent laboratory light and tubidity was measured. The samples are assessed immediately after preparation and at one, four and twenty-four hours. Physicochemical changes such as precipitation, color change, turbidity change or decrease of cyclosporine concentration were monitored to validate compatibility results.