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[특집] 신생아용 고영양수액과 Ceftriaxone 혼합의 적합성 실험
Compatibility Test of Neonatal Parenteral Nutrient Solutions with Ceftriaxone

Authors: 정경주, 송인숙, 조하령, 최승기, 이승우^*
포천중문의과대학교 분당차병원 약제부, ^*중외제약 품질관리부
Kyong Ju Jeong, In Suk Song, Ha Ryung Cho, Seung Ki Choi and Seung Woo Lee^*
Department of pharmacy, Pundang CHA General Hospital, College of Medicine, Pochon CHA University
^*Quality Control Dept., Choongwae Pharma Corporation
#351, Yatap-dong, Pundang-gu, Sungnam-city, Kyonggi-do, 463-070, Korea
#146-141, Annyung-ri, Taean-eup, Hwansung-kun, Kyonggi-do, 445-970, Korea^*

Keyword: Compatibility, Stability, Ceftriaxone, Neonatal parenteral nutrient solutions, Calcium sale, Precipitation

Abstract: The purpose of this study was to evaluate the compatibility/stability of ceftriaxone with neonatal parenteral nutrient solutions. The concentration of ceftriaxone was determined by recommended dosage commonly used in NICU. Two neonatal parenteral nutrient solutions were mixed with TrophAmine. Admixture was prepared in duplicate and stored at 37℃ water bath for each hour. Each mixture was investigated for pH, visual inspection, HPLC assay of ceftriaxone, atomic absorption spectrometry of calcium ion. An obvious pricipitate which occurred within 1-4 hours after mixing with PN solution was yielded on these mixtures. Despite various aspects of precipitations, calcium salts of ceftriaxone revealed to be a component of the precipitation. In progress, the residual concentrations of ceftriaxone/calcium ion decreased to 20-80%. Accordingly, if ceftriaxone is administered through the PN line, flush the line with normal saline before and after each administration. The infusion of parenteral nutrient solution should be temporily stopped during administration the ceftriaxone.

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